Frey K A, Minoshima S, Koeppe R A, Kilbourn M R, Berger K L, Kuhl D E
Department of Internal Medicine, The University of Michigan, Ann Arbor, USA.
J Cereb Blood Flow Metab. 1996 May;16(3):409-17. doi: 10.1097/00004647-199605000-00007.
Summation analysis strategies are recognized throughout diverse scientific fields as powerful means of differentially enhancing experimental signals over random fluctuations (noise). Such techniques, applied to emission tomographic cerebral blood flow scans, reveal subtle alterations in neuronal activity during specific behavioral states. In the present work, we extend the principles of intersubject image summation analysis to the evaluation of emission tomographic ligand-binding studies. A general methodology is presented that may be applied to a wide variety of binding site determinations. The procedure consists of anatomic standardization of individual brains to a common stereotaxic orientation, followed by statistical analyses of group versus group or individual versus group differences. We develop and evaluate performance of our technique with the use of positron emission tomographic [11C]flumazenil scans from normal volunteers, depicting the regional cerebral distribution of benzodiazepine binding sites.
求和分析策略在不同科学领域都被视为一种强大的手段，可用于在随机波动（噪声）之上差异性地增强实验信号。将此类技术应用于发射断层脑血流扫描时，可揭示特定行为状态下神经元活动的细微变化。在本研究中，我们将个体间图像求和分析的原理扩展到发射断层配体结合研究的评估中。我们提出了一种通用方法，该方法可应用于多种结合位点的测定。该程序包括将个体大脑标准化到共同的立体定向方向，然后进行组间或个体与组间差异的统计分析。我们使用来自正常志愿者的正电子发射断层扫描[11C]氟马西尼扫描来开发和评估我们技术的性能，该扫描描绘了苯二氮䓬结合位点的区域脑分布。
