Jordana G, Dolovich J, Briscoe M P, Day J H, Drouin M A, Gold M, Robson R, Stepner N, Yang W
Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada.
J Allergy Clin Immunol. 1996 Feb;97(2):588-95. doi: 10.1016/s0091-6749(96)70303-2.
Fluticasone propionate (FP) is a topical corticosteroid with minimal systemic activity. We examined safety and compared the efficacy of FP aqueous nasal spray, 200 micrograms every day with loratadine tablets, 10 mg by mouth every day in 240 adolescents with ragweed pollen-induced seasonal allergic rhinitis for 4 weeks in a randomized, double-blind, parallel-group study. Nasal and eye symptoms were recorded daily on a 4-point (0 to 3) scale. A higher percentage of symptom-free days was observed for nasal blockage on waking during treatment with FP (p < 0.0001). Significant results were also obtained for all other nasal symptoms when analyzed for both symptom-free days and symptom scores. No differences were found for eye irritation symptoms (p = 0.14). Morning and evening nasal peak inspiratory flow (PIF) was recorded daily by 57 subjects. FP treatment was associated wit significantly higher PIF values than loratadine both morning (p = 0.0051) and evening (p = 0.0036). A greater improvement over 4 weeks was observed for PIF morning values in the FP group (p = 0.008) but not for evening values (p = 0.358). Statistically significant correlations were found for nasal blockage and PIF in the morning (r = -0.54, p = 0.0001) and in the evening (r = -0.46, p = 0.008).
丙酸氟替卡松（FP）是一种全身活性极小的局部用皮质类固醇。在一项随机、双盲、平行组研究中，我们对240名患有豚草花粉引起的季节性过敏性鼻炎的青少年进行了为期4周的研究，比较了每天200微克的FP水性鼻喷雾剂与每天口服10毫克氯雷他定片的安全性和疗效。每天以4分制（0至3分）记录鼻和眼症状。在使用FP治疗期间，观察到醒来时鼻塞无症状天数的百分比更高（p < 0.0001）。在分析无症状天数和症状评分时，所有其他鼻部症状也得到了显著结果。眼部刺激症状未发现差异（p = 0.14）。57名受试者每天记录早晚的鼻峰吸气流量（PIF）。FP治疗在早晨（p = 0.0051）和晚上（p = 0.0036）的PIF值均显著高于氯雷他定。FP组早晨PIF值在4周内有更大改善（p = 0.008），但晚上的值没有（p = 0.358）。在早晨（r = -0.54，p = 0.0001）和晚上（r = -0.46，p = 0.008），鼻塞与PIF之间存在统计学显著相关性。
