Miyazaki Y, Hashimoto M, Kinuya S, Satake R, Inoue H, Shiozaki J, Takimoto M, Ito H, Tonami N
Section of Nuclear Medicine, Noto General Hospital, Japan.
Kaku Igaku. 1996 Mar;33(3):285-91.
We intended to improve the fractional uptake (FU) method which was developed to quantify cerebral blood flow using 123I-IMP without blood sampling. The quantification of cardiac output (CO) using first-pass data was adapted to FU method while the original FU method used CO which was estimated from the body surface area of patients. Time-radioactivity curves of the lungs and brain were separately obtained by a small-field-of-view gamma camera. In 24 cases, mean cerebral blood flow (mCBF) obtained by the modified FU method showed the better correlation (r = 0.833, P< 0.001) to mCBF measured by the Patlak plot with 99mTc-HMPAO than the original FU method (r=0.667, p<0.01). With these modifications, the reliability of FU method could be improved and the modified FU method might be performed in the other institutions.
我们旨在改进分数摄取（FU）法，该方法是为使用123I-IMP在不进行采血的情况下量化脑血流量而开发的。利用首次通过数据对心输出量（CO）进行量化并应用于FU法，而原始FU法使用的是根据患者体表面积估算的CO。通过小视野γ相机分别获取肺和脑的时间-放射性曲线。在24例病例中，改良FU法获得的平均脑血流量（mCBF）与采用99mTc-HMPAO的Patlak图测量的mCBF相比，相关性更好（r = 0.833，P < 0.001），而原始FU法的相关性为（r = 0.667，p < 0.01）。通过这些改进，FU法的可靠性得以提高，改良后的FU法或许可在其他机构开展。
