Hachiya T, Hayasaka M, Honda T, Takeda M, Hayano T, Fujimoto K, Kubo K, Sekiguchi M, Hanyuuda M
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto City, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Feb;34(2):204-9.
We report two cases of primary Sjögren's syndrome with pulmonary involvement, in which open lung biopsies were done. The patient in the first case was a 58-year-old woman and the patient in the second case was a 54-year-old woman. Both patients were admitted to our hospital because of dry coughing and exertional dyspnea. Chest X-ray films and CT scans showed interstitial shadows in both cases and multiple bullae in the first case. Pulmonary-function tests showed decreased diffusing capacity, and examination of bronchoalveolar lavage fluid revealed increased percentages of lymphocytes. Open-lung biopsy specimens showed thickening of the alveolar septa and interstitial mononuclear cell infiltration, composed predominantly of lymphocytes, with lymphoid follicles in both cases, and peribronchiolar mononuclear cell infiltration in the first case. Therefore, the histopathological diagnosis was cellular interstitial pneumonia with lymphoid follicles. Both patients were treated with oral corticosteroids. Symptoms were relieved and laboratory findings improved.
我们报告两例原发性干燥综合征合并肺部受累的病例，并对其进行了开胸肺活检。第一例患者为一名58岁女性，第二例患者为一名54岁女性。两名患者均因干咳和劳力性呼吸困难入院。胸部X线片和CT扫描显示两例均有间质性阴影，第一例有多个肺大疱。肺功能测试显示弥散功能下降，支气管肺泡灌洗液检查显示淋巴细胞百分比增加。开胸肺活检标本显示肺泡间隔增厚和间质单核细胞浸润，主要由淋巴细胞组成，两例均有淋巴滤泡，第一例有支气管周围单核细胞浸润。因此，组织病理学诊断为伴有淋巴滤泡的细胞性间质性肺炎。两名患者均接受口服糖皮质激素治疗。症状缓解，实验室检查结果改善。
