重度妊娠子痫前期/子痫中特异性HLA抗体缺乏
Deficienty of specific HLA antibodies in severe pregnancy pre-eclampsia/eclampsia.
作者信息
Jenkins D M, Need J, Kajah S M
出版信息
Clin Exp Immunol. 1977 Mar;27(3):485-6.
Abstract
The paradox of the survival of the foetal allograft remains unresolved as does the aetiology of pre-eclampsia/eclampsia--the principle disease of pregnancy. In a prospective study of very severe cases of pre-eclampsia we have found significantly reduced antibody to paternal histocompatibility antigens. Lowered immune response to the foetal allograft may play a role in severe cases of pre-eclampsia.
摘要
胎儿同种异体移植物存活的悖论仍未得到解决，子痫前期/子痫（妊娠的主要疾病）的病因也是如此。在一项针对非常严重的子痫前期病例的前瞻性研究中，我们发现针对父系组织相容性抗原的抗体显著减少。对胎儿同种异体移植物的免疫反应降低可能在严重子痫前期病例中起作用。
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引用本文的文献
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本文引用的文献
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Leucocytotoxic antibodies and preeclamptic toxaemia of pregnancy.白细胞毒性抗体与妊娠子痫前期
Transplantation. 1971 Oct;12(4):319-21. doi: 10.1097/00007890-197110000-00015.
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Immunosuppression by micromolecular fibrinogen degradation products in cancer.癌症中微分子纤维蛋白原降解产物引起的免疫抑制
Nature. 1976 Feb 5;259(5542):399-401. doi: 10.1038/259399a0.
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