豚鼠肾毒性肾炎II. 自体期：补体激活但无明显损伤。
Guinea-pig nephrotoxic nephritis II. Autologous phase: complement activation without detectable injury.
作者信息
Simpson I J, Thomson N M, Amos N, Evans D J, Peters D K
出版信息
Clin Exp Immunol. 1977 Apr;28(1):146-52.
In the autologous phase of nephrotoxic induced by sheep antibody to glomerular basement membrane (GBM) in Dunkin-Hartley and C4 deficient strain guinea-pigs, less than 50% of animals developed proteinuria at the height of the autologous antibody response despite high anti-sheep immunolglobulin tetres and fixation of guinea-pig IgG and complement in the kidney. tonly two of thirty-sdven animals (5-4%) developed progressive. In a passive model of autologous phase injury using high titres rabbit antibody to sheep IgG, proteinuria failed to occur despite fixation of up to 95 microng rabbit antibody per kidney. Repeated injection of sheep nephrotoxic antibody (NTab) caused a persisting nephrotic syndrome but not the characteristic proliferative lesion of anti GBM diseases in other species.
在Dunkin-Hartley豚鼠和C4缺陷型豚鼠中，用抗肾小球基底膜（GBM）羊抗体诱导肾毒性的自身免疫阶段，尽管自身抗体反应高峰期抗羊免疫球蛋白水平很高，且豚鼠IgG和补体在肾脏中沉积，但不到50%的动物出现蛋白尿。37只动物中只有2只（5.4%）出现病情进展。在使用高滴度兔抗羊IgG抗体的自身免疫阶段损伤被动模型中，尽管每只肾脏沉积高达95微克兔抗体，但蛋白尿并未出现。反复注射羊肾毒性抗体（NTab）会导致持续性肾病综合征，但不会导致其他物种抗GBM疾病的特征性增殖性病变。
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