非竞争性N-甲基-D-天冬氨酸受体拮抗剂对阿扑吗啡诱导的小鼠攀爬行为的抑制作用。

Inhibition by noncompetitive NMDA receptor antagonists of apomorphine-induced climbing behavior in mice.

作者信息

Kim H S, Rhee G S, Jung J Y, Lee J H, Jang C G, Park W K

机构信息

Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.

出版信息

Life Sci. 1996;58(17):1397-402. doi: 10.1016/0024-3205(96)00109-9.

DOI:10.1016/0024-3205(96)00109-9

PMID:8622565

Abstract

The N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is an important mediator of several forms of neural and behavioral plasticity. In the present study, we examined the potential role of NMDA receptors in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine receptor by determining the effects of NMDA antagonists on apomorphine-induced climbing behavior in mice. The noncompetitive NMDA receptor antagonists, MK-801, ketamine, dextrorphan, and dextromethorphan attenuated the apomorphine-induced climbing behavior at does well below those that produce untoward side effects. These results suggest that the NMDA receptors play important roles in the glutamatergic modulation of dopaminergic function at the postsynaptic dopamine receptors that mediate the apomorphine-induced climbing behavior in mice.

摘要

谷氨酸受体的N-甲基-D-天冬氨酸（NMDA）亚型是多种神经和行为可塑性形式的重要介质。在本研究中，我们通过确定NMDA拮抗剂对阿扑吗啡诱导的小鼠攀爬行为的影响，研究了NMDA受体在突触后多巴胺受体处对多巴胺能功能的谷氨酸能调节中的潜在作用。非竞争性NMDA受体拮抗剂MK-801、氯胺酮、右啡烷和右美沙芬在远低于产生不良副作用剂量的情况下减弱了阿扑吗啡诱导的攀爬行为。这些结果表明，NMDA受体在介导阿扑吗啡诱导的小鼠攀爬行为的突触后多巴胺受体处对多巴胺能功能的谷氨酸能调节中起重要作用。