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NMDA receptor antagonists enhance 5-HT2 receptor-mediated behavior, head-twitch response, in mice.

作者信息

Kim H S, Park I S, Park W K

机构信息

College of Pharmacy, Chungbuk National University, Cheongju, Korea.

出版信息

Life Sci. 1998;63(26):2305-11. doi: 10.1016/s0024-3205(98)00519-0.

DOI:10.1016/s0024-3205(98)00519-0
PMID:9877220
Abstract

The purpose of this study was to characterize behavioral interactions between glutamatergic and serotonergic 5-HT2 receptors. Both competitive (AP-5 [D-2-amino-5-phosphovalerate] and D-CPP [3-(2carboxypiperazine-4yl)-propylphosphonate]) and noncompetitive (MK-801 [dizocilpine], ketamine, dextrorphan and dextromethorphan) N-methyl-D-aspartate (NMDA) receptor antagonists markedly enhanced a selective serotonergic behavior, the head twitch response (HTR), in mice. In contrast, NMDA itself inhibited 5-hydroxytryptamine (5-HT)-induced HTR in mice. These results suggest that glutamatergic neurotransmission may modulate serotonergic function at the 5-HT2 receptor.

摘要

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