Lai Z C, Moss M B, Killiany R J, Rosene D L, Herndon J G
Department of Anatomy and Neurobiology, Boston University School of Medicine, MA 02118, USA.
Neurobiol Aging. 1995 Nov-Dec;16(6):947-54. doi: 10.1016/0197-4580(95)02014-4.
As part of the effort to characterize age-related cognitive changes in executive system function in a nonhuman primate model of human aging, the performance of seven rhesus monkeys, 20 to 28 years of age, was compared to that of five young adult monkeys, 6 to 11 years of age, on spatial and object reversal tasks. No differences in performance were found between the two groups in the initial learning of either task. On spatial reversals, aged monkeys were impaired relative to young adults, but there was no difference in overall performance between the groups on object reversals. Central to this article, a perseverative tendency was noted in the aged group on both spatial and object reversal tasks. Changes in executive system dysfunction may represent an important aspect of age-related cognitive decline.
作为在人类衰老的非人灵长类动物模型中描述与年龄相关的执行系统功能认知变化工作的一部分，将7只20至28岁的恒河猴的表现与5只6至11岁的年轻成年猴子在空间和物体反转任务上的表现进行了比较。在两项任务的初始学习中，两组之间的表现没有差异。在空间反转任务上，老年猴子相对于年轻成年猴子表现受损，但在物体反转任务上，两组之间的整体表现没有差异。本文的核心是，在老年组的空间和物体反转任务中都观察到了一种固着倾向。执行系统功能障碍的变化可能代表了与年龄相关的认知衰退的一个重要方面。
