Facilitating oligonucleotide delivery: helping antisense deliver on its promise.
作者信息
Gewirtz A M, Stein C A, Glazer P M
机构信息
Department of Pathology, University of Pennsylvania School of Medicine,Philadelphia, 19104, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3161-3. doi: 10.1073/pnas.93.8.3161.
Abstract
摘要
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Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair.三链螺旋形成和转录偶联修复诱导的哺乳动物细胞诱变。
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In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide.一种形成三链体的寡核苷酸可特异性抑制孕酮反应基因的体内转录。
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The third helix of the Antennapedia homeodomain translocates through biological membranes.触角足同源异型域的第三个螺旋穿过生物膜。
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Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide.与融合肽偶联的反义寡核苷酸的生物活性增强。
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Gene targeting in the mouse.小鼠中的基因靶向
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Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation.由细胞内三链螺旋形成介导的哺乳动物细胞中的靶向诱变。
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