Facilitating oligonucleotide delivery: helping antisense deliver on its promise.
作者信息
Gewirtz A M, Stein C A, Glazer P M
机构信息
Department of Pathology, University of Pennsylvania School of Medicine,Philadelphia, 19104, USA.
出版信息
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3161-3. doi: 10.1073/pnas.93.8.3161.
Abstract
摘要
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本文引用的文献
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Mutagenesis in mammalian cells induced by triple helix formation and transcription-coupled repair.三链螺旋形成和转录偶联修复诱导的哺乳动物细胞诱变。
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Delivery of antisense oligonucleotides by poly(L-lysine) conjugation and liposome encapsulation.通过聚（L-赖氨酸）偶联和脂质体包封递送反义寡核苷酸。
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Cellular pharmacology of phosphorothioate homooligodeoxynucleotides in human cells.硫代磷酸酯同型寡脱氧核苷酸在人细胞中的细胞药理学
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In vivo transcription of a progesterone-responsive gene is specifically inhibited by a triplex-forming oligonucleotide.一种形成三链体的寡核苷酸可特异性抑制孕酮反应基因的体内转录。
Nucleic Acids Res. 1993 Jun 25;21(12):2789-96. doi: 10.1093/nar/21.12.2789.
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Biologic and therapeutic significance of MYB expression in human melanoma.MYB表达在人类黑色素瘤中的生物学及治疗学意义
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The third helix of the Antennapedia homeodomain translocates through biological membranes.触角足同源异型域的第三个螺旋穿过生物膜。
J Biol Chem. 1994 Apr 8;269(14):10444-50.
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Improved biological activity of antisense oligonucleotides conjugated to a fusogenic peptide.与融合肽偶联的反义寡核苷酸的生物活性增强。
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Targeted mutagenesis in mammalian cells mediated by intracellular triple helix formation.由细胞内三链螺旋形成介导的哺乳动物细胞中的靶向诱变。
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