Bornstein N M, Gur A Y, Treves T A, Reider-Groswasser I, Aronovich B D, Klimovitzky S S, Varssano D, Korczyn A D
Department of Neurology, Tel Aviv Medical Center, Israel.
Stroke. 1996 May;27(5):904-5. doi: 10.1161/01.str.27.5.904.
Silent brain infarctions (SBI) are common findings in advanced age, but their relationship to dementia is still uncertain. The present study was designed to evaluate whether SBI predict the development of dementia after first clinical ischemic stroke.
We blindly studied admission CT scans of 175 consecutive nondemented patients presenting with ischemic stroke that clinically was their first stroke episode. SBI were defined as CT evidence of infarcts not compatible with the acute event. The patients were subsequently followed for their mental state for 5 years. Survival analysis, wherein onset of dementia was the end point, was performed on the total sample population and conducted separately on those with and without SBI at admission.
Dementia developed in 56 patients (32%), including 22 of the 63 (35%) with SBI and 34 of the 112 (30%) without SBI. Thus, dementia was not related to SBI.
Our data indicate that SBI do not predict the development of dementia after stroke.
无症状脑梗死（SBI）在老年人中很常见，但其与痴呆的关系仍不确定。本研究旨在评估SBI是否能预测首次临床缺血性卒中后痴呆的发生。
我们对175例连续的非痴呆患者的入院CT扫描进行了盲法研究，这些患者表现为缺血性卒中，临床上为首次卒中发作。SBI被定义为与急性事件不相符的梗死CT证据。随后对患者的精神状态进行了5年的随访。以痴呆发作作为终点进行生存分析，对总样本人群进行分析，并分别对入院时有无SBI的患者进行分析。
56例患者（32%）发生痴呆，其中63例中有22例（35%）有SBI，112例中无SBI的有34例（30%）。因此，痴呆与SBI无关。
我们的数据表明，SBI不能预测卒中后痴呆的发生。
