Department of Neurology, Haukeland University Hospital, Bergen, Norway.
J Neurol Sci. 2012 Jan 15;312(1-2):138-41. doi: 10.1016/j.jns.2011.08.002. Epub 2011 Aug 20.
To evaluate characteristics and mortality related to post-stroke fatigue (PSF).
All surviving stroke patients admitted to the Stroke Unit, Haukeland University Hospital, between February 2006 and November 2008 were sent a postal questionnaire including the Fatigue Severity Scale (FSS), the hospital anxiety and depression scale (HADSD), and the Barthel Index (BI) at least 6 months after stroke onset. Survival among patients returning the questionnaire was determined by November 2009. PSF was defined as FSS score ≥5.
Among 377 patients returning the questionnaire, 42.3% had PSF. Logistic regression showed that PSF was independently associated with pre-stroke depression, leucoaraiosis, myocardial infarction, diabetes mellitus, pain, and sleeping disturbances. Mean FSS score was lower among TIA patients than among patients with minor cerebral infarction (patients with BI=100) (P=.002). Cox regression analysis showed mortality to be associated with PSF.
There is a multifactorial basis for PSF suggesting different therapy options. Cerebral lesions may cause PSF in some patients. Post-stroke fatigue is associated with higher mortality.
评估与中风后疲劳（PSF）相关的特征和死亡率。
2006 年 2 月至 2008 年 11 月期间，所有入住豪克兰大学医院中风病房的存活中风患者均会在发病至少 6 个月后收到一份包括疲劳严重程度量表（FSS）、医院焦虑和抑郁量表（HADSD）和巴氏指数（BI）在内的邮寄问卷。通过 2009 年 11 月来确定回复问卷的患者的生存情况。PSF 的定义为 FSS 评分≥5。
在 377 名回复问卷的患者中，42.3%患有 PSF。Logistic 回归显示，PSF 与中风前抑郁、脑白质疏松症、心肌梗死、糖尿病、疼痛和睡眠障碍独立相关。与小面积脑梗死患者（BI=100）相比，短暂性脑缺血发作患者的平均 FSS 评分较低（P=.002）。Cox 回归分析显示，PSF 与死亡率相关。
PSF 的发生存在多因素基础，提示有不同的治疗选择。脑部病变可能会导致某些患者出现 PSF。中风后疲劳与更高的死亡率相关。
