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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Rubinfeld A R, Pain M C

Clin Sci Mol Med. 1977 Apr;52(4):423-8. doi: 10.1042/cs0520423.

Lung volumes, airway resistance and flow/volume curves were measured in ten asthmatic subjects at times when tightness in the chest was just sensed (threshold symptom). 2. These measurements when the threshold symptom was induced by methacholine inhalation were compared with those when a similar symptom occurred spontaneously, in the same subjects. 3. Values during the methacholine-induced thresholds were very similar to those observed when threshold symptoms developed spontaneously. 4. Controlled bronchial provocation mimics spontaneous asthma sufficiently well to allow this technique to be used in the study of sensations associated with breathing. This has some advantages over the already established models utilizing external hindrances to breathing.

在10名哮喘患者刚感觉到胸部发紧（阈值症状）时，测量其肺容积、气道阻力和流量/容积曲线。2. 将这些在通过吸入乙酰甲胆碱诱发阈值症状时所做的测量结果，与同一批受试者自发出现类似症状时的测量结果进行比较。3. 乙酰甲胆碱诱发阈值时的值与阈值症状自发出现时观察到的值非常相似。4. 控制性支气管激发试验对自发性哮喘的模拟效果足够好，使得该技术可用于研究与呼吸相关的感觉。这比已有的利用外部呼吸阻碍的模型具有一些优势。

Rubinfeld A R, Pain M C

Clin Sci Mol Med. 1977 Apr;52(4):423-8. doi: 10.1042/cs0520423.

Lung volumes, airway resistance and flow/volume curves were measured in ten asthmatic subjects at times when tightness in the chest was just sensed (threshold symptom). 2. These measurements when the threshold symptom was induced by methacholine inhalation were compared with those when a similar symptom occurred spontaneously, in the same subjects. 3. Values during the methacholine-induced thresholds were very similar to those observed when threshold symptoms developed spontaneously. 4. Controlled bronchial provocation mimics spontaneous asthma sufficiently well to allow this technique to be used in the study of sensations associated with breathing. This has some advantages over the already established models utilizing external hindrances to breathing.

在10名哮喘患者刚感觉到胸部发紧（阈值症状）时，测量其肺容积、气道阻力和流量/容积曲线。2. 将这些在通过吸入乙酰甲胆碱诱发阈值症状时所做的测量结果，与同一批受试者自发出现类似症状时的测量结果进行比较。3. 乙酰甲胆碱诱发阈值时的值与阈值症状自发出现时观察到的值非常相似。4. 控制性支气管激发试验对自发性哮喘的模拟效果足够好，使得该技术可用于研究与呼吸相关的感觉。这比已有的利用外部呼吸阻碍的模型具有一些优势。