Rubinfeld A R, Pain M C
Thorax. 1977 Apr;32(2):177-81. doi: 10.1136/thx.32.2.177.
Nineteen asthmatic volunteers underwent methacholine-induced asthma to the point when tightness in the chest was just sensed (threshold symptom). Changes in the following indices of lung function were measured--static lung volumes, forced expiratory volume in one second, and airways conductance. The increase in airways resistance necessary for threshold detection was at least double that previously reported in experiments using external resistive loads. Despite the mildness of the symptom, increases in lung volumes to the levels previously described during acute and severe asthma were occasionally found. It is emphasised that there may be little leeway in respiratory reserve between the development of minor and severe symptoms in some asthmatic patients.
19名哮喘志愿者接受了乙酰甲胆碱诱发的哮喘，直至刚感觉到胸部发紧（阈值症状）。测量了以下肺功能指标的变化——静态肺容量、一秒用力呼气量和气道传导率。检测到阈值所需的气道阻力增加至少是先前使用外部阻力负荷的实验中所报告的两倍。尽管症状较轻，但偶尔也会发现肺容量增加到先前在急性和重度哮喘中所描述的水平。需要强调的是，在一些哮喘患者中，轻微症状和严重症状的发展之间，呼吸储备可能几乎没有回旋余地。
