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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Trippodo N C, Hall J E, Lohmeier T E, Guyton A C

Clin Sci Mol Med. 1977 May;52(5):545-8. doi: 10.1042/cs0520545.

The intrarenal role of angiotensin II in controlling sodium excretion was examined in anaesthetized, dehydrated dogs by infusing the angiotensin II antagonist Sar1-Ile8-angiotensin II directly into the renal artery. Comparisons were made with dehydrated dogs receiving only sodium chloride solution intrarenally. 2. Intrarenal angiotensin II blockade resulted in significant increases in urinary sodium excretion and urine flow rate. 3. The results indicate that during the high-renin state of dehydration endogenous angiotensin II has intrarenal effects which lead to salt and water retention.

通过将血管紧张素II拮抗剂Sar1-Ile8-血管紧张素II直接注入肾动脉，在麻醉、脱水的狗身上研究了血管紧张素II在控制钠排泄方面的肾内作用。将其与仅在肾内接受氯化钠溶液的脱水狗进行比较。2. 肾内血管紧张素II阻断导致尿钠排泄和尿流率显著增加。3. 结果表明，在脱水的高肾素状态下，内源性血管紧张素II具有肾内作用，导致盐和水潴留。

Trippodo N C, Hall J E, Lohmeier T E, Guyton A C

Clin Sci Mol Med. 1977 May;52(5):545-8. doi: 10.1042/cs0520545.

The intrarenal role of angiotensin II in controlling sodium excretion was examined in anaesthetized, dehydrated dogs by infusing the angiotensin II antagonist Sar1-Ile8-angiotensin II directly into the renal artery. Comparisons were made with dehydrated dogs receiving only sodium chloride solution intrarenally. 2. Intrarenal angiotensin II blockade resulted in significant increases in urinary sodium excretion and urine flow rate. 3. The results indicate that during the high-renin state of dehydration endogenous angiotensin II has intrarenal effects which lead to salt and water retention.

通过将血管紧张素II拮抗剂Sar1-Ile8-血管紧张素II直接注入肾动脉，在麻醉、脱水的狗身上研究了血管紧张素II在控制钠排泄方面的肾内作用。将其与仅在肾内接受氯化钠溶液的脱水狗进行比较。2. 肾内血管紧张素II阻断导致尿钠排泄和尿流率显著增加。3. 结果表明，在脱水的高肾素状态下，内源性血管紧张素II具有肾内作用，导致盐和水潴留。