Mossafa H, Troussard X, Valensi F, Schillinger F, Maynadie M, Bulliard G, Macintyre E, Flandrin G
Déparment de Génétique Humaine, Laboratoire Cerba, Cergy-Pontoise, France.
Leuk Lymphoma. 1996 Jan;20(3-4):267-73. doi: 10.3109/10428199609051617.
Chronic B lymphocytosis with binucleated lymphocytes (LWBL) is a recently described entity. The lymphocytosis is stable over years and atypical binucleated lymphocytes are detected on peripheral blood smears. Further investigation has shown a predominance in females, a polyclonal increase in serum IgM and HLA-DR7 expression in most cases. In almost all cases cytogenetic studies with classical culture conditions have not shown any abnormality. We describe 7 patients with LWBL associated with an abnormal karyotype. An additional i(3q) was found in 6 cases. Premature chromosome condensation (PCC) was detected in all 7 cases. As both abnormalities are rarely present in other benign or malignant proliferations, we suggest a strong correlation between LWBL and i(3q) and/or PCC.
伴有双核淋巴细胞的慢性B淋巴细胞增多症（LWBL）是一种最近才被描述的疾病实体。淋巴细胞增多症多年来保持稳定，在外周血涂片上可检测到非典型双核淋巴细胞。进一步研究表明，该病在女性中更为常见，多数病例血清IgM呈多克隆性增加，且表达HLA - DR7。几乎在所有病例中，采用经典培养条件进行的细胞遗传学研究均未显示任何异常。我们描述了7例伴有异常核型的LWBL患者。6例患者发现额外的i(3q)。所有7例均检测到早熟染色体凝集（PCC）。由于这两种异常在其他良性或恶性增殖中很少出现，我们认为LWBL与i(3q)和/或PCC之间存在密切关联。
