Eschwege P, Benoit G, Blanchet P, Alexandre L, Hesse C, Zucman D, Edouard A, Decaux A, Bensadoun H, Andraud F, Chanson P, Bouchard P, Jardin A, Charpentier B
Service d'Urologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
Prog Urol. 1996 Feb;6(1):30-6.
Twenty five double kidney-pancreas transplantations were performed according to the total pancreas transplantation technique with drainage of exocrine secretions into the bladder via a vesicoduodenostomy. 72% of kidney-pancreas grafts were functional at one year and 59% were functional at four years. The authors observed a slightly higher rejection rate (0.56 versus 0.34) and a higher incidence of urinary tract infection (60% versus 35%) following double pancreas and renal transplantation than after isolated renal transplantation. Complications were rare: two venous thromboses and two cases of urethritis requiring of rediversion of the duodenum into the intestine. These good results, comparable to those reported in the international registry, reflect the value of the pancreatic and renal transplantation technique using a total pancreas drained into the bladder. It would probably be preferable to transplant patients earlier, when chronic renal failure secondary to insulin-dependent diabetes induces end-stage renal failure and the need for haemodialysis.
根据全胰移植技术，通过膀胱十二指肠吻合术将外分泌液引流至膀胱，进行了25例双肾胰联合移植。72%的肾胰移植物在1年时功能良好，59%在4年时功能良好。作者观察到，与单纯肾移植相比，双胰肾联合移植后的排斥反应率略高（0.56对0.34），尿路感染发生率更高（60%对35%）。并发症罕见：发生了2例静脉血栓形成和2例需要将十二指肠重新引流至肠道的尿道炎病例。这些与国际登记处报告结果相当的良好结果，反映了使用全胰引流至膀胱的胰肾移植技术的价值。当胰岛素依赖型糖尿病继发的慢性肾衰竭导致终末期肾衰竭并需要进行血液透析时，尽早为患者进行移植可能更为可取。
