Balsa A, Dixey J, Sansom D M, Maddison P J, Hall N D
Bath Institute for Rheumatic Diseases, Royal National Hospital for Rheumatic Diseases, Bath, UK.
Br J Rheumatol. 1996 Jan;35(1):33-7. doi: 10.1093/rheumatology/35.1.33.
CD4+ T-lymphocytes require two signals to become activated--antigen receptor (TcR) occupancy and an antigen-presenting cell (APC)-derived costimulus. The latter may be provided by B7.1 (CD80) or B7.2 (CD86) on APC interacting with CD28 on T-cells. We have studied the expression of these costimulatory molecules in rheumatoid and osteoarthritic synovial membrane. Very few B7.1-positive cells were seen in synovial tissue from either established or early rheumatoid disease, or in rheumatoid arthritis (RA) or osteoarthritis (OA) synovia at arthroplasty. In contrast, B7.2 was readily detected in rheumatoid synovia, predominantly in the lining layer, in a pattern of expression that corresponded to the presence of CD68-positive macrophages. Only occasional B7.2-positive cells were seen in OA synovia. The presence of B7.2 but the relative lack of expression of B7.1 may be partly responsible for the observations of 'frustrated' T-cell activation or T-cell hyporesponsiveness in the rheumatoid synovium.
CD4 + T淋巴细胞需要两个信号才能被激活——抗原受体（TcR）占据以及抗原呈递细胞（APC）衍生的共刺激信号。后者可由APC上的B7.1（CD80）或B7.2（CD86）与T细胞上的CD28相互作用提供。我们研究了这些共刺激分子在类风湿性和骨关节炎滑膜中的表达。在已确诊的或早期类风湿疾病的滑膜组织中，或在关节置换术时的类风湿关节炎（RA）或骨关节炎（OA）滑膜中，很少见到B7.1阳性细胞。相比之下，在类风湿滑膜中很容易检测到B7.2，主要在衬里层，其表达模式与CD68阳性巨噬细胞的存在相对应。在OA滑膜中仅偶尔见到B7.2阳性细胞。B7.2的存在但B7.1相对缺乏表达可能部分解释了类风湿滑膜中“受阻”的T细胞激活或T细胞反应低下的现象。
