Hamzaoui A, Hamzaoui K, Chabbou A, Ayed K
Department of Respiratory Diseases, Faculty of Medicine of Tunis, Tunisia.
Br J Rheumatol. 1996 Apr;35(4):357-8. doi: 10.1093/rheumatology/35.4.357.
In view of the pulmonary manifestations in Behçet's disease (BD), we investigated the production of endothelin-1 (ET-1) by the respiratory tract in active BD. A group of 10 patients with active BD with pulmonary manifestations and 10 control subjects were studied. Immunoreactive ET-1 was measured in BAL and in serum by RIA. All the BD patients exhibited higher BAL ET-1 levels than controls. ET-1 expression may contribute to the functional and morphological abnormalities of the vasculature associate with BD.
鉴于白塞病（BD）的肺部表现，我们研究了活动期BD患者呼吸道中内皮素-1（ET-1）的产生情况。研究了一组10例有肺部表现的活动期BD患者和10例对照者。通过放射免疫分析法（RIA）检测支气管肺泡灌洗（BAL）液和血清中的免疫反应性ET-1。所有BD患者的BAL液ET-1水平均高于对照组。ET-1的表达可能导致与BD相关的血管系统功能和形态异常。
