Gao M, Nakabayashi M, Sakura M, Takeda Y
Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.
J Obstet Gynaecol Res. 1996 Feb;22(1):9-16. doi: 10.1111/j.1447-0756.1996.tb00928.x.
To evaluate the role of plasminogen activators (tPA uPA) and inhibitor (PAI-1) in the pathogenesis of preeclampsia.
tPA uPA and PAI-1 antigens were measured in amniotic fluid, maternal plasma, and placental homogenates in normal pregnancy by ELISA method and compared with that of preeclampsia.
In normal pregnancy, tPA, uPA and PAI-1 levels increase as the gestation advance, but the increment of PAI-1 in amniotic fluid (28.3-fold) is larger than that of tPA and uPA (1.8-fold, 8.5-fold) (p < 0.001). Decidua homogenates contained larger amount of PAI-1 than villi. Whereas, villi had higher levels of tPA uPA than decidua (p < 0.01). In preeclampsia, the significantly higher levels of PAI-1 were observed in AF and decidua tissue as compared to the normals (p < 0.01), and the increment of PAI-1 in preeclampsia is larger than that of tPA, uPA.
The elevated PAI-1 level is associated with the preeclampsia and the imbalance between the plasminogen activators (tPA, uPA) and the inhibitor (PAI-1) might be involved in the pathogenesis of preeclampsia.
评估纤溶酶原激活剂（tPA、uPA）及抑制剂（PAI-1）在子痫前期发病机制中的作用。
采用酶联免疫吸附测定法（ELISA法）检测正常妊娠孕妇羊水、母血血浆及胎盘匀浆中tPA、uPA及PAI-1抗原水平，并与子痫前期患者进行比较。
正常妊娠时，tPA、uPA及PAI-1水平随孕周增加而升高，但羊水中PAI-1升高幅度（28.3倍）大于tPA及uPA（分别为1.8倍、8.5倍）（p<0.001）。蜕膜匀浆中PAI-1含量高于绒毛，而绒毛中tPA、uPA水平高于蜕膜（p<0.01）。子痫前期患者羊水中及蜕膜组织中PAI-1水平显著高于正常孕妇（p<0.01），子痫前期患者PAI-1升高幅度大于tPA、uPA。
PAI-1水平升高与子痫前期有关，纤溶酶原激活剂（tPA、uPA）与抑制剂（PAI-1）之间的失衡可能参与子痫前期的发病机制。
