子痫前期中纤溶酶原激活剂与抑制剂的失衡。

The imbalance of plasminogen activators and inhibitor in preeclampsia.

作者信息

Gao M, Nakabayashi M, Sakura M, Takeda Y

机构信息

Maternal and Perinatal Center, Tokyo Women's Medical College, Japan.

出版信息

J Obstet Gynaecol Res. 1996 Feb;22(1):9-16. doi: 10.1111/j.1447-0756.1996.tb00928.x.

DOI:10.1111/j.1447-0756.1996.tb00928.x

PMID:8624901

Abstract

OBJECTIVE

To evaluate the role of plasminogen activators (tPA uPA) and inhibitor (PAI-1) in the pathogenesis of preeclampsia.

STUDY DESIGN

tPA uPA and PAI-1 antigens were measured in amniotic fluid, maternal plasma, and placental homogenates in normal pregnancy by ELISA method and compared with that of preeclampsia.

RESULTS

In normal pregnancy, tPA, uPA and PAI-1 levels increase as the gestation advance, but the increment of PAI-1 in amniotic fluid (28.3-fold) is larger than that of tPA and uPA (1.8-fold, 8.5-fold) (p < 0.001). Decidua homogenates contained larger amount of PAI-1 than villi. Whereas, villi had higher levels of tPA uPA than decidua (p < 0.01). In preeclampsia, the significantly higher levels of PAI-1 were observed in AF and decidua tissue as compared to the normals (p < 0.01), and the increment of PAI-1 in preeclampsia is larger than that of tPA, uPA.

CONCLUSIONS

The elevated PAI-1 level is associated with the preeclampsia and the imbalance between the plasminogen activators (tPA, uPA) and the inhibitor (PAI-1) might be involved in the pathogenesis of preeclampsia.

摘要

目的

评估纤溶酶原激活剂（tPA、uPA）及抑制剂（PAI-1）在子痫前期发病机制中的作用。

研究设计

采用酶联免疫吸附测定法（ELISA法）检测正常妊娠孕妇羊水、母血血浆及胎盘匀浆中tPA、uPA及PAI-1抗原水平，并与子痫前期患者进行比较。

结果

正常妊娠时，tPA、uPA及PAI-1水平随孕周增加而升高，但羊水中PAI-1升高幅度（28.3倍）大于tPA及uPA（分别为1.8倍、8.5倍）（p<0.001）。蜕膜匀浆中PAI-1含量高于绒毛，而绒毛中tPA、uPA水平高于蜕膜（p<0.01）。子痫前期患者羊水中及蜕膜组织中PAI-1水平显著高于正常孕妇（p<0.01），子痫前期患者PAI-1升高幅度大于tPA、uPA。