Kohlberger P, Kainz C, Breitenecker G, Gitsch G, Sliutz G, Kölbl H, Tschachler E, Reinthaller A
Department of Gynecology and Obstetrics, Vienna University Medical School, Austria.
Cancer. 1995 Nov 15;76(10):1786-9. doi: 10.1002/1097-0142(19951115)76:10<1786::aid-cncr2820761016>3.0.co;2-5.
Overexpression of the p53 protein has been reported to correlate with poor prognosis in several types of tumors. To the authors' knowledge, there are no studies concerning the prognostic value of p53 protein overexpression in squamous cell vulvar carcinoma.
Twenty-five cases of squamous cell carcinoma of the vulva with International Federation of Gynecology and Obstetrics (FIGO) Stage I-II were examined for p53 protein overexpression using immunohistochemistry. The correlation of p53 protein overexpression with clinical stage, histologic grade, and overall survival was investigated. Follow-up ranged from 36 to 120 months.
Clinical stage and histologic grade did not correlate with p53 protein overexpression. p53 protein overexpression was associated with poorer overall survival (log rank: P < 0.05).
Immunohistochemically detected p53 protein overexpression is significantly correlated with a reduced overall survival rate for patients with vulvar carcinoma.
据报道，p53蛋白过表达与多种肿瘤的预后不良相关。据作者所知，尚无关于p53蛋白过表达在外阴鳞状细胞癌中的预后价值的研究。
采用免疫组织化学法检测25例国际妇产科联盟（FIGO）I-II期外阴鳞状细胞癌患者的p53蛋白过表达情况。研究p53蛋白过表达与临床分期、组织学分级和总生存率的相关性。随访时间为36至120个月。
临床分期和组织学分级与p53蛋白过表达无关。p53蛋白过表达与较差的总生存率相关（对数秩检验：P < 0.05）。
免疫组织化学检测到的p53蛋白过表达与外阴癌患者总生存率降低显著相关。
