Ansorge Nadine, Dannecker Christian, Jeschke Udo, Schmoeckel Elisa, Mayr Doris, Heidegger Helene H, Vattai Aurelia, Burgmann Maximiliane, Czogalla Bastian, Mahner Sven, Fuerst Sophie
Department of Obstetrics and Gynecology, University Hospital, LMU Munich, Marchionini Str. 15, 81377 Munich, Germany.
Department of Obstetrics and Gynecology, University Hospital Augsburg, Stenglinstr. 2, 86156 Augsburg, Germany.
Diagnostics (Basel). 2021 Mar 10;11(3):491. doi: 10.3390/diagnostics11030491.
Vulvar cancer incidence numbers have been rising steadily over the past decades. Especially the number of young patients with vulvar cancer increased recently. Therefore, the need to identify new prognostic factors for vulvar carcinoma is more apparent. Cyclooxygenase-2 (COX-2) has long been an object of scientific interest in the context of carcinogenesis. This enzyme is involved in prostaglandin synthesis and the latter binds to nuclear receptors like PPARγ. Therefore, the aim of this study was to investigate COX-2- and PPARγ- expression in tissues of vulvar carcinomas and to analyze their relevance as prognostic factors. The cytoplasmatic expression of COX-2 as well as PPARγ is associated with a significantly reduced survival, whereas nuclear expression of PPARγ results in a better survival. Especially the combined expression of both COX-2 and PPARγ in the cytoplasm is an independent negative prognosticator for vulvar cancer patients.
在过去几十年中，外阴癌的发病率一直在稳步上升。特别是近年来，年轻外阴癌患者的数量有所增加。因此，识别外阴癌新的预后因素的需求更加明显。长期以来，环氧化酶-2（COX-2）一直是致癌作用背景下的科学研究对象。这种酶参与前列腺素的合成，而前列腺素与PPARγ等核受体结合。因此，本研究的目的是调查COX-2和PPARγ在外阴癌组织中的表达，并分析它们作为预后因素的相关性。COX-2以及PPARγ的细胞质表达与生存率显著降低相关，而PPARγ的核表达则导致更好的生存率。特别是COX-2和PPARγ在细胞质中的联合表达是外阴癌患者独立的不良预后指标。
