Clement D J, Stanley M S, Attwell N A, Clipson N J, Fincham D A, Hooley P
School of Applied Sciences, University of Wolverhampton, Wulfruna Street, Wolverhampton, West Midlands, WV1 1LY, UK.
Curr Genet. 1996 Apr;29(5):462-7.
Strains of Aspergillus nidulans carrying the sltA1 mutation, conferring sensitivity to KCl and NaCl, also showed an arginine-sensitive phenotype whereby concentrations of the L-amino acid at or above 10 mM were toxic to growth. Sexual progeny of a cross between a sltA1 mutant and a wild-type strain showed a co-segregation of salt and arginine sensitivity. Similarly, revertants to salt tolerance showed a loss of arginine sensitivity as did sltA1 strains that were transformed with a cosmid carrying the putative sltA1+ wild-type allele. In addition, arginine sensitivity could be relieved by L-ornithine. It is suggested that sltA1 is a salt-sensitive allele of the arginase gene (agaA).
携带sltA1突变的构巢曲霉菌株对氯化钾和氯化钠敏感，同时也表现出精氨酸敏感的表型，即L-氨基酸浓度达到或高于10 mM时对生长有毒害作用。sltA1突变体与野生型菌株杂交的有性子代显示出盐敏感性和精氨酸敏感性的共分离。同样，耐盐回复突变体表现出精氨酸敏感性的丧失，用携带假定的sltA1+野生型等位基因的黏粒转化的sltA1菌株也是如此。此外，L-鸟氨酸可以缓解精氨酸敏感性。有人提出sltA1是精氨酸酶基因（agaA）的一个盐敏感等位基因。
