Yamanaka K, Ohtsubo K, Hasegawa A, Hayashi H, Ohji H, Kanisawa M, Okada S
Department of Biochemical Toxicology, Nihon University College of Pharmacy, Chiba, Japan.
Carcinogenesis. 1996 Apr;17(4):767-70. doi: 10.1093/carcin/17.4.767.
The effect of dimethylarsenics on the pulmonary tumorigenesis initiated by 4-nitroquinoline 1-oxide (4NQO) in mice was examined. The exposure of mice to dimethylarsinic acid (DMAA), a major metabolite of inorganic arsenics in mammals, resulted in not only promotion but also progression of the tumorigenic process in the lungs of mice administered 4NQO. Furthermore, dimethylarsenics influenced the differentiation process in lung tumorigenesis by 4NQO. These results may pave the way for the elucidation of lung carcinogenesis caused by arsenics.
研究了二甲基砷对4-硝基喹啉-1-氧化物（4NQO）引发的小鼠肺肿瘤发生的影响。将小鼠暴露于无机砷在哺乳动物中的主要代谢产物二甲基砷酸（DMAA），不仅导致给予4NQO的小鼠肺部肿瘤发生过程的促进，还导致其进展。此外，二甲基砷影响了4NQO所致肺肿瘤发生中的分化过程。这些结果可能为阐明砷引起的肺癌发生铺平道路。
