Miller R A, Thaut M H, McIntosh G C, Rice R R
Department of Electrical Engineering, Colorado State University, Fort Collins, 80523, USA.
Electroencephalogr Clin Neurophysiol. 1996 Feb;101(1):1-7. doi: 10.1016/0013-4694(95)00209-x.
Variability and bilateral symmetry of EMG gait-cycle profiles were studied in parkinsonian and healthy elderly subjects in the gastrocnemius, tibialis anterior, and vastus lateralis muscles. Components reflecting shape and timing were defined by the magnitude and phase of the cross-correlation function between individual stride profiles and the latency corrected ensemble average (LCEA) (variability), and between bilateral LCEAs (symmetry). Statistical significance was set at a confidence level of 0.01 reflecting a Bonferroni adjustment due to multiple measures. Parkinsonian gait was significantly different from the healthy elderly in several measures: increased shape variability and asymmetry in the gastrocnemius and tibialis anterior muscles, and reduced timing variability in the gastrocnemius. A portion of the parkinsonian group participated in a 3 week therapy program where they walked to rhythmic auditory stimulation. Gait parameters shifted toward healthy elderly values in each measure where population differences were found. Significant changes were observed in decreased tibialis anterior shape variability and asymmetry, and gastrocnemius shape variability. Strong trends were also observed in increased gastrocnemius timing variability and reduced bilateral asymmetry. In addition to the expected decreased in variability and asymmetry of healthy elderly, increased timing variability in the gastrocnemius was associated with a more normal gait, possibly reflecting feedback adaptability of muscle activity which may be useful in generating stable locomotion.
在帕金森病患者和健康老年人中，研究了腓肠肌、胫骨前肌和股外侧肌的肌电图步态周期图谱的变异性和双侧对称性。反映形状和时间的成分由个体步幅图谱与潜伏期校正总体平均值（LCEA）之间互相关函数的幅度和相位（变异性）以及双侧LCEA之间（对称性）来定义。由于进行了多项测量，统计显著性设定为0.01的置信水平，以反映Bonferroni校正。帕金森病步态在几个指标上与健康老年人有显著差异：腓肠肌和胫骨前肌的形状变异性和不对称性增加，腓肠肌的时间变异性降低。一部分帕金森病患者组参加了为期3周的治疗项目，在有节奏的听觉刺激下行走。在发现有群体差异的每个指标中，步态参数都向健康老年人的值转变。观察到显著变化包括胫骨前肌形状变异性和不对称性降低，以及腓肠肌形状变异性降低。还观察到强烈趋势，即腓肠肌时间变异性增加和双侧不对称性降低。除了健康老年人预期的变异性和不对称性降低外，腓肠肌时间变异性增加与更正常的步态相关，这可能反映了肌肉活动的反馈适应性，这可能有助于产生稳定的运动。
