Gomez G, Padilla L, Udupi V, Tarasova N, Sundler F, Townsend C M, Thompson J C, Greeley G H
Department of Surgery, University of Texas Medical Branch, Galveston, 77555, USA.
Endocrinology. 1996 Apr;137(4):1365-9. doi: 10.1210/endo.137.4.8625912.
Peptide YY (PYY) is a gut hormone localized primarily in the distal bowel. Because circulating PYY inhibits gastric acid secretion, we investigated the effects of gastric acid secretion and gastrin on gene expression and secretion of PYY. In conscious dogs, PYY release in response to oral food was inhibited (P < 0.05) by pharmacologic inhibition of gastric acid secretion (omeprazole, famotidine). In rats, omeprazole treatment resulted in a significant elevation in serum gastrin concentrations and a simultaneous decrease in PYY messenger RNA (mRNA) and peptide levels in the colon; administration of a gastrin receptor antagonist (L365, 260) prevented the inhibitory actions of omeprazole on colonic PYY mRNA levels. In athymic-nude mice, implantation of a human gastrinoma resulted in an elevation of serum gastrin concentrations and a concomitant depression of colonic PYY mRNA levels. We conclude that endogenous gastric acid secretion up-regulates PYY release and PYY mRNA expression. Circulating gastrin acts to down-regulate PYY release and PYY mRNA expression. This study provides evidence that foregut functions (i.e., gastric acid secretion and gastrin release) exert control over an antiacid signal (e.g. PYY release) emanating from the hindgut.
肽YY（PYY）是一种主要定位于远端肠道的胃肠激素。由于循环中的PYY会抑制胃酸分泌，我们研究了胃酸分泌和胃泌素对PYY基因表达及分泌的影响。在清醒犬中，通过药物抑制胃酸分泌（奥美拉唑、法莫替丁）可抑制口服食物后PYY的释放（P<0.05）。在大鼠中，奥美拉唑治疗导致血清胃泌素浓度显著升高，同时结肠中PYY信使核糖核酸（mRNA）和肽水平降低；给予胃泌素受体拮抗剂（L365,260）可防止奥美拉唑对结肠PYY mRNA水平的抑制作用。在无胸腺裸鼠中，植入人胃泌素瘤导致血清胃泌素浓度升高，同时结肠PYY mRNA水平降低。我们得出结论，内源性胃酸分泌上调PYY释放和PYY mRNA表达。循环中的胃泌素则下调PYY释放和PYY mRNA表达。本研究提供了证据，表明前肠功能（即胃酸分泌和胃泌素释放）对来自后肠的抗酸信号（如PYY释放）发挥控制作用。
