Hashimoto T, Lluis F, Gomez G, Hill F L, Greeley G H, Thompson J C
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
Dig Dis Sci. 1991 Jul;36(7):888-92. doi: 10.1007/BF01297136.
The purpose of this study was to examine the effect of perfusion of the colon with a fatty acid (oleic acid) on peptone-stimulated gastric acid secretion and release of gastrin in conscious dogs. Gastric acid secretion was monitored by continuous intragastric titration. Perfusion of the colon with sodium oleate (24 mmol/hr) inhibited gastric acid secretion (14.2 +/- 2.6 meq/hr) stimulated by a peptone meal (1%) significantly (P less than 0.05) when compared to perfusion of the colon with saline alone (20.1 +/- 1.6 meq/hr). The serum elevation in gastrin in response to intragastric instillation of the peptone meal was not affected by the colonic perfusion of oleic acid. Plasma concentrations of peptide YY (PYY) increased significantly in response to perfusion of the colon with saline or sodium oleate, and the integrated release of PYY in response to sodium oleate [6.9 +/- 2.8 ng (60-120) min/ml] was significantly greater than the response to saline [3.1 +/- 0.7 ng (60-120) min/ml]. The results of this study indicate that inhibition of gastric acid secretion by perfusion of the colon with fat is not due to an inhibition of gastrin release. In addition, because PYY is an inhibitor of gastric acid secretion, it is possible that PYY participates as an inhibitor of gastric acid secretion by the colon.
本研究的目的是检测用脂肪酸（油酸）灌注结肠对清醒犬中蛋白胨刺激的胃酸分泌及胃泌素释放的影响。胃酸分泌通过连续胃内滴定法进行监测。与单独用生理盐水灌注结肠（20.1±1.6毫当量/小时）相比，用橄榄油酸钠（24毫摩尔/小时）灌注结肠显著抑制了蛋白胨餐（1%）刺激的胃酸分泌（14.2±2.6毫当量/小时）（P<0.05）。胃内注入蛋白胨餐引起的胃泌素血清升高不受结肠灌注油酸的影响。用生理盐水或橄榄油酸钠灌注结肠后，肽YY（PYY）的血浆浓度显著升高，且对橄榄油酸钠的反应中PYY的累积释放量[6.9±2.8纳克/（60 - 120）分钟/毫升]显著大于对生理盐水的反应[3.1±0.7纳克/（60 - 120）分钟/毫升]。本研究结果表明，用脂肪灌注结肠抑制胃酸分泌并非由于胃泌素释放受到抑制。此外，由于PYY是胃酸分泌的抑制剂，因此PYY有可能作为结肠分泌胃酸的抑制剂发挥作用。
