Kraut R, Campos-Ortega J A
Institut für Entwicklungsbiologie, Universität zu Köln, Cologne, Germany.
Dev Biol. 1996 Feb 25;174(1):65-81. doi: 10.1006/dbio.1996.0052.
In Drosophila, neural precursor genes are expressed in neural progenitor cells as the neuroblasts and sense organ mother cells. These genes are thought to control the fate and/or behavior of neural progenitor cells once their fate decision has been made. We have isolated and characterized a novel neural precursor gene, inscuteable, whose expression is coincident with sites of cell shape changes or cell and tissue movement in the embryo, e.g., neuroblasts, trachea, Malphigian tubules, and in pupal wing epithelia. The Inscuteable protein is localized to the apical submembranous surface of neuroblasts and other cell types and shows certain features common to a family of putative cytoskeletal associated proteins. The inscuteable mutant phenotype, together with these other observations, suggests a possible role for the protein in cytoskeleton organization.
在果蝇中，神经前体基因在神经祖细胞中表达，如神经母细胞和感觉器官母细胞。一旦神经祖细胞做出命运决定，这些基因被认为可以控制其命运和/或行为。我们分离并鉴定了一个新的神经前体基因——无定向基因（inscuteable），其表达与胚胎中细胞形状变化或细胞及组织移动的部位一致，如神经母细胞、气管、马氏管以及蛹期翅上皮。无定向蛋白定位于神经母细胞和其他细胞类型的顶端亚膜表面，并显示出与一类假定的细胞骨架相关蛋白家族共有的某些特征。无定向突变体表型以及其他这些观察结果表明，该蛋白在细胞骨架组织中可能发挥作用。
