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Antascomicins A, B, C, D and E. Novel FKBP12 binding compounds from a Micromonospora strain.

作者信息

Fehr T, Sanglier J J, Schuler W, Gschwind L, Ponelle M, Schilling W, Wioland C

机构信息

Sandoz Pharma Ltd., Basel, Switzerland.

出版信息

J Antibiot (Tokyo). 1996 Mar;49(3):230-3. doi: 10.7164/antibiotics.49.230.

DOI:10.7164/antibiotics.49.230
PMID:8626235
Abstract

5 novel ascomycin-like compounds, antascomicins A, B, C, D and E were isolated from a strain of Micromonospora. The antascomicins bind strongly to the FK506-binding protein FKBP12 and antagonize the immunosuppressive activity of FK506 and rapamycin. The strain description, fermentation, structure elucidation and biological activity of these compounds are described.

摘要

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J Antibiot (Tokyo). 1996 Mar;49(3):230-3. doi: 10.7164/antibiotics.49.230.
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