Lingham R B, Hsu A H, O'Brien J A, Sigmund J M, Sanchez M, Gagliardi M M, Heimbuch B K, Genilloud O, Martin I, Diez M T, Hirsch C F, Zink D L, Liesch J M, Koch G E, Gartner S E, Garrity G M, Tsou N N, Salituro G M
Merck Research Laboratories, Rahway, NJ 07065, U.S.A.
J Antibiot (Tokyo). 1996 Mar;49(3):253-9. doi: 10.7164/antibiotics.49.253.
Quinoxapeptin A and B are novel chromodepsipeptides which were isolated from a nocardioform actinomycete with indeterminant morphology. Quinoxapeptins A and B are potent inhibitors of HIV-1 and HIV-2 reverse transcriptase and almost equally active against two single mutants forms as well as a double mutant form of HIV-1 reverse transcriptase. Quinoxapeptin A and B are specific inhibitors of HIV-1 and HIV-2 reverse transcriptase because they did not inhibit human DNA polymerase alpha, beta, gamma and delta. Quinoxapeptin A and B are structurally similar to luzopeptin A which was also active against HIV-1 and HIV-2 reverse transcriptase.
