来自链霉菌属E225的新型米尔倍霉素类抗生素。发酵、分离及结构解析。
Further novel milbemycin antibiotics from Streptomyces sp. E225. Fermentation, isolation and structure elucidation.
作者信息
Baker G H, Blanchflower S E, Dorgan R J, Everett J R, Manger B R, Reading C R, Readshaw S A, Shelley P
机构信息
SmithKline Beecham Animal Health, Tadworth, Surrey, England.
出版信息
J Antibiot (Tokyo). 1996 Mar;49(3):272-80. doi: 10.7164/antibiotics.49.272.
Ten novel alpha and beta class milbemycins have been isolated and characterized from the Streptomyces sp. E225, which has previously been shown to produce four related milbemycins. Some of the metabolites contain new structural features including, VM48641 which possesses an alpha-methoxyl substituent at C-27, and VM48642 which contains a furan ring at the terminus of the C-26 side chain. Several of these new compounds were shown to possess potent anthelmintic activity. An analysis of NMR chemical shift trends in this series of metabolites is presented.
从链霉菌属菌株E225中分离并鉴定出了十种新型的α和β类米尔倍霉素，该菌株此前已被证明能产生四种相关的米尔倍霉素。一些代谢产物具有新的结构特征，包括在C-27位具有α-甲氧基取代基的VM48641，以及在C-26侧链末端含有呋喃环的VM48642。这些新化合物中有几种显示出强效的驱虫活性。本文对这一系列代谢产物的核磁共振化学位移趋势进行了分析。
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