米尔倍霉素α11、α12、α13、α14和α15：来自吸水链霉菌金色泪滴亚种的一个新的米尔倍霉素家族。分类学、发酵、分离、结构解析及生物学特性

Milbemycins alpha 11, alpha 12, alpha 13, alpha 14 and alpha 15: a new family of milbemycins from Streptomyces hygroscopicus subsp. aureolacrimosus. Taxonomy, fermentation, isolation, structure elucidation and biological properties.

作者信息

Takahashi S, Miyaoka H, Tanaka K, Enokita R, Okazaki T

机构信息

Fermentation Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.

出版信息

J Antibiot (Tokyo). 1993 Sep;46(9):1364-71. doi: 10.7164/antibiotics.46.1364.

DOI:10.7164/antibiotics.46.1364

PMID:8226315

Abstract

Streptomyces hygroscopicus subsp. aureolacrimosus SANK 60286 produces a new family of milbemycins, named milbemycins alpha 11, alpha 12 [corrected], alpha 13, alpha 14 and alpha 15, together with other milbemycins. Their structures are 3-methyl-2-butenoyloxy and 3-methylbutyroyloxy derivatives at C-4a of milbemycins A3 and A4, or 3-methyl-2-pentenoyloxy derivative at C-4a of milbemycin A3, respectively. Milbemycin alpha 14, 3-methyl-2-butenoyloxy derivative, especially possesses a potent acaricidal activity.

摘要

吸水链霉菌金色泪滴亚种SANK 60286产生了一个新的米尔倍霉素家族，命名为米尔倍霉素α11、α12[已修正]、α13、α14和α15，以及其他米尔倍霉素。它们的结构分别是米尔倍霉素A3和A4的C-4a位的3-甲基-2-丁烯酰氧基和3-甲基丁酰氧基衍生物，或者是米尔倍霉素A3的C-4a位的3-甲基-2-戊烯酰氧基衍生物。米尔倍霉素α14，即3-甲基-2-丁烯酰氧基衍生物，尤其具有强大的杀螨活性。