van Dam G J, Stelma F F, Gryseels B, Falcão Ferreira S T, Talla I, Niang M, Rotmans J P, Deelder A M
Department of Parasitology, University of Leiden, Netherlands.
J Infect Dis. 1996 May;173(5):1232-41. doi: 10.1093/infdis/173.5.1232.
Acquired immune resistance is believed to be largely responsible for age-dependent infection and reinfection patterns in schistosomiasis. In a recently established but intense focus of Schistosoma mansoni in Senegal, the humoral immune response was studied in a random population sample of 289. Antibody levels of various isotypes to schistosome worm and egg antigens were determined by ELISA and related to egg counts (eggs per gram of feces [EPG]), age, and sex. Both IgG1 and IgG4 followed age-related patterns similar to egg counts and strongly correlated with EPG, even after allowing for age. Specific IgE levels increased slowly with age. The humoral immune response patterns in this recently infected population appeared to be largely similar to those in chronically infected communities. Thus far, the observations do not support the current hypothesis that age-related resistance to Schistosoma is determined by IgE-mediated protective immunity acquired during many years of exposure.
获得性免疫抗性被认为在很大程度上导致了血吸虫病中与年龄相关的感染和再感染模式。在塞内加尔一个最近形成但曼氏血吸虫感染严重的地区，对289名随机抽取的人群样本进行了体液免疫反应研究。通过酶联免疫吸附测定法（ELISA）测定了针对血吸虫虫体和虫卵抗原的各种同种型抗体水平，并将其与虫卵计数（每克粪便中的虫卵数[EPG]）、年龄和性别相关联。IgG1和IgG4均呈现出与年龄相关的模式，类似于虫卵计数，并且即使在考虑年龄因素后，仍与EPG密切相关。特异性IgE水平随年龄缓慢升高。在这个最近感染的人群中，体液免疫反应模式似乎与慢性感染社区的模式基本相似。到目前为止，这些观察结果并不支持当前的假说，即与年龄相关的对血吸虫的抗性是由多年接触期间获得的IgE介导的保护性免疫所决定的。
