Lieberman S A, Hoffman A R
Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555-1060, USA.
J Pediatr. 1996 May;128(5 Pt 2):S58-60. doi: 10.1016/s0022-3476(96)70013-6.
Despite adequate adrenal, gonadal, and thyroid hormone replacement, many adults with hypopituitarism have a recognizable syndrome of weakness and diminished sense of well-being, accompanied by alterations in metabolism and body composition, as well as increased mortality. Short-term treatment with human growth hormone improves many of these abnormalities, but a clear improvement in functional status has yet to be demonstrated. Until such an effect is shown, the use of growth hormone replacement in adults with hypopituitarism remains investigational.
尽管进行了充分的肾上腺、性腺和甲状腺激素替代治疗，但许多垂体功能减退的成年人仍有明显的虚弱综合征和幸福感下降，伴有代谢和身体成分的改变以及死亡率增加。短期使用人生长激素可改善其中许多异常情况，但功能状态的明显改善尚未得到证实。在这种效果得到证实之前，垂体功能减退的成年人使用生长激素替代治疗仍处于研究阶段。
