SU 23397的绝对构型：一种新型抗精神病药物。
The absolute configuration of SU 23397: a novel neuroleptic agent.
作者信息
Chaudhuri N K, Ball T J, Finch N
出版信息
Experientia. 1977 May 15;33(5):575-7. doi: 10.1007/BF01946504.
PMID:862771
Abstract
The absolute configuration of a novel chiral neuroleptic agent SU 23397 (I) was determined by ORD comparison of (+)-5-methoxy dihydro coumarilic acid (VIII), a synthetic precursor of SU 23397 (I), with (+)-dihydro coumarilic acid, whose absolute configuration is known. This assignment was confirmed by oxidative degradation of (+)-5-methoxy dihydro coumarilic acid VIII to D-(+)-malic acid.
摘要
通过将新型手性抗精神病药物SU 23397（I）的合成前体（+）-5-甲氧基二氢香豆酸（VIII）与绝对构型已知的（+）-二氢香豆酸进行旋光色散比较，确定了SU 23397（I）的绝对构型。通过将（+）-5-甲氧基二氢香豆酸VIII氧化降解为D-（+）-苹果酸，证实了这一构型归属。
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