Nihrane A, Fujita K, Willey R, Lyu M S, Silver J
Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-0460, USA.
J Virol. 1996 Mar;70(3):1882-9. doi: 10.1128/JVI.70.3.1882-1889.1996.
Transgenic mice bearing a murine retroviral envelope transgene (Fv4) have Fv4 gp70env (SU) in their serum in amounts sufficient to block infection by ecotropic virus in vitro. Fv4 Env in serum is derived largely but not exclusively from hematopoietic cells. Tail cells from Fv4 mice and cell lines transduced with the Fv4 env transgene synthesize both components of the envelope protein (gp70 SU and p15E TM) but secrete the gp70 moiety, in the absence of retroviral particles. Blocking of the ecotropic viral receptor by secreted gp70 SU may contribute to resistance to retroviral infection in these mice.
携带鼠逆转录病毒包膜转基因（Fv4）的转基因小鼠血清中含有Fv4 gp70env（SU），其含量足以在体外阻断嗜亲性病毒的感染。血清中的Fv4 Env主要但并非完全来源于造血细胞。Fv4小鼠的尾细胞以及用Fv4 env转基因转导的细胞系在没有逆转录病毒颗粒的情况下合成包膜蛋白的两种成分（gp70 SU和p15E TM），但分泌gp70部分。分泌的gp70 SU对嗜亲性病毒受体的阻断可能有助于这些小鼠对逆转录病毒感染产生抗性。
