In vivo effect of gamma ray pretreatment on sister-chromatid exchange induction by mitomycin C in murine bone marrow cells.
作者信息
Morales-Ramírez P, Cruz-Vallejo V
机构信息
Departamento de Genética, Instituto Nacional de Investigaciones Nucleares, México, D.F., Mexico.
出版信息
Mutat Res. 1996 Apr 6;367(4):225-32. doi: 10.1016/s0165-1218(96)90081-6.
PMID:8628329
Abstract
The effect of gamma ray pretreatment on sister-chromatid exchange induction by mitomycin C (MMC) was determined in murine bone marrow cells in vivo. A 30% reduction in the expected SCE frequency was observed assuming an additive effect. These results support the prediction of the replicative model for SCE formation with regard to the interactions between mutagens, and confirm previous results focused on the adaptive response.
摘要
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