细胞周期依赖性组蛋白H1磷酸化对染色质结构和染色质复制的影响。
Effects of cell cycle dependent histone H1 phosphorylation on chromatin structure and chromatin replication.
作者信息
Halmer L, Gruss C
机构信息
Division of Biology, Universität Konstanz, Germany.
出版信息
Nucleic Acids Res. 1996 Apr 15;24(8):1420-7. doi: 10.1093/nar/24.8.1420.
Abstract
We have reconstituted salt-treated SV40 minichromosomes with differentially phosphorylated forms of histone H1 extracted from either G0-, S- or M-phase cells. Sedimentation studies revealed a clear difference between minichromosomes reconstituted with S-phase histone H1 compared with histone H1 from G0- or M-phase cells, indicating that the phosphorylation state of histone H1 has a direct effect on chromatin structure. Using reconstituted minichromosomes as substrate in the SV40 in vitro replication system, we measured a higher replication efficiency for SV40 minichromosomes reconstituted with S-phase histone H1 compared with G0- or M-phase histone H1. These data indicate that the chromatin structure induced by the phosphorylation of histone H1 influences the replication efficiency of SV40 minichromosomes in vitro.
摘要
我们用从G0期、S期或M期细胞中提取的不同磷酸化形式的组蛋白H1重构了盐处理的SV40微型染色体。沉降研究表明，与用G0期或M期细胞的组蛋白H1重构的微型染色体相比，用S期组蛋白H1重构的微型染色体存在明显差异，这表明组蛋白H1的磷酸化状态对染色质结构有直接影响。在SV40体外复制系统中，我们以重构的微型染色体为底物，测定发现与用G0期或M期组蛋白H1重构的SV40微型染色体相比，用S期组蛋白H1重构的SV40微型染色体具有更高的复制效率。这些数据表明，组蛋白H1磷酸化诱导的染色质结构影响了SV40微型染色体在体外的复制效率。
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