Young V L, Lund H, Ueda K, Pidgeon L, Schorr M W, Kreeger J
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, USA.
Plast Reconstr Surg. 1996 May;97(6):1179-93; discussion 1194-5. doi: 10.1097/00006534-199605000-00012.
Radiolucent breast implants filled with triglyceride oil have recently entered limited clinical trials. To investigate the questions of oil bleed and the fate of triglycerides that might escape from ruptured breast implants, experiments reported here used peanut oil labeled with radioisotopes so that it could be traced in the urine, feces, and organs of two groups of rabbits. In one experiment, 18 rabbits were implanted with peanut oil-filled implants labeled with tritium to determine whether triglycerides diffuse across silicone elastomer shells. In another experiment, 19 rabbits were injected with 14C-labeled peanut oil to study what might happen to the oil if an implant ruptures. At the end of the follow-up period, we measured radioisotope levels in tissue samples taken from the periprosthetic capsule or injection site of each rabbit, as well as from major organs and the subcutaneous fat on the dorsum opposite the experimental site. One experiment revealed that triglycerides do bleed across the implant shells. Tritium levels were highest in the implant capsule, the omentum, the aorta, and the subcutaneous fat on the nonexperimental side. In the experiment simulating implant rupture, 14C levels were above the background radiation count at the injection site and in the same tissue sites as in the bleed experiment. Both in vivo radiolabeling studies indicate that triglycerides freed from implants by means of bleed or rupture would be absorbed, metabolized, and either excreted or redistributed to the body's normal fat storage sites if they are not needed for energy. In a third in vitro experiment, triglyceride oil specimens were inoculated with various microorganisms associated with wound infections: Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Staphylococcus epidermidis, and diphtheroids. The data demonstrate that neutral triglycerides used as a breast implant filler do not support growth of common infection-producing bacteria and suggest that triglycerides may have bactericidal properties.
填充甘油三酯油的放射性透性乳房植入物最近已进入有限的临床试验阶段。为了研究油渗漏问题以及可能从破裂的乳房植入物中逸出的甘油三酯的去向，本文报道的实验使用了用放射性同位素标记的花生油，以便在两组兔子的尿液、粪便和器官中追踪它。在一个实验中，给18只兔子植入了用氚标记的填充花生油的植入物，以确定甘油三酯是否会扩散穿过硅橡胶弹性体外壳。在另一个实验中，给19只兔子注射了14C标记的花生油，以研究如果植入物破裂，油会发生什么情况。在随访期结束时，我们测量了从每只兔子的假体周围囊或注射部位以及主要器官和与实验部位相对的背部皮下脂肪中采集的组织样本中的放射性同位素水平。一个实验表明甘油三酯确实会渗漏穿过植入物外壳。氚水平在植入物囊、网膜、主动脉和非实验侧的皮下脂肪中最高。在模拟植入物破裂的实验中，14C水平在注射部位以及与渗漏实验相同的组织部位高于本底辐射计数。两项体内放射性标记研究均表明，通过渗漏或破裂从植入物中释放出来的甘油三酯如果能量不需要，将会被吸收、代谢，然后排出或重新分布到身体的正常脂肪储存部位。在第三个体外实验中，用与伤口感染相关的各种微生物接种甘油三酯油标本：金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌、表皮葡萄球菌和类白喉杆菌。数据表明，用作乳房植入物填充物的中性甘油三酯不支持常见感染产生细菌的生长，并表明甘油三酯可能具有杀菌特性。
