Evans G R, Netscher D T, Schusterman M A, Kroll S S, Robb G L, Reece G P, Miller M J
Department of Plastic Surgery, University of Texas, M.D. Anderson Cancer Center, Houston, USA.
Plast Reconstr Surg. 1996 May;97(6):1207-14. doi: 10.1097/00006534-199605000-00016.
Tissue silicon assays were performed on 10 nonaugmented cadavers and 25 augmented women to confirm our previous cadaveric data and to establish silicon levels at local and distant sites in augmented women undergoing explant and further reconstruction. All assays were performed by inductively coupled plasma atomic emissions spectroscopy (ICP-AES). Cadaveric tissues were sampled from six sites: liver, spleen, breast, nipple, axilla (soft tissue and nodes), and subcutaneous tissue (abdominal). Augmented women undergoing explant surgery had a portion of their implant capsule, breast tissue, and for those undergoing autogenous reconstruction, a portion of the autogenous donor site or distant tissue sampled. Twenty-four women had silicone implants; one had saline. Results revealed baseline silicon levels in all 10 non-augmented cadavers. These results were equivalent to our previous data, confirming the validity of these baseline data. Silicon tissue levels in the 25 augmented women revealed elevated levels within the implant capsule and surrounding breast tissue. However, silicon levels obtained from distant sites in augmented women were equivalent to the baseline nonaugmented cadaveric levels. There was no correlation between intact or ruptured implants and symptoms of collagen-vascular disease. In conclusion, study validates our original data of baseline silicon levels in nonaugmented cadavers. Contrary to what some may perceive as silicone floating throughout the body, we have found elevated levels around the implant only, and levels at distant tissue sites were equivalent to the baseline cadaveric data.
对10具未隆胸的尸体和25名隆胸女性进行了组织硅含量检测，以证实我们之前的尸体数据，并确定接受隆胸假体取出及进一步重建手术的隆胸女性局部和远处部位的硅含量水平。所有检测均采用电感耦合等离子体原子发射光谱法（ICP - AES）进行。从六个部位采集尸体组织样本：肝脏、脾脏、乳房、乳头、腋窝（软组织和淋巴结）以及皮下组织（腹部）。接受隆胸假体取出手术的隆胸女性，采集了一部分植入物包膜、乳房组织样本；对于接受自体组织重建的女性，则采集了一部分自体供区组织或远处组织样本。24名女性植入的是硅胶假体，1名女性植入的是盐水假体。结果显示了所有10具未隆胸尸体的基线硅含量水平。这些结果与我们之前的数据一致，证实了这些基线数据的有效性。25名隆胸女性的硅组织水平显示，植入物包膜和周围乳房组织中的硅含量升高。然而，隆胸女性远处部位的硅含量水平与未隆胸尸体的基线水平相当。完整或破裂的假体与胶原血管疾病症状之间没有相关性。总之，该研究验证了我们关于未隆胸尸体基线硅含量水平的原始数据。与一些人认为硅胶会在全身流动的观点相反，我们发现仅植入物周围的硅含量升高，而远处组织部位的硅含量水平与尸体基线数据相当。
