Evans G R, Baldwin B J
Department of Plastic Surgery, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Ann Plast Surg. 1996 Dec;37(6):592-5. doi: 10.1097/00000637-199612000-00004.
In previous studies, we were able to demonstrate baseline non-augmented cadaveric silicon tissue values as well as silicone-augmented breast capsular tissue silicon levels from various geographic locations in the United States. One of the limitations of these previous studies was the potential for intracapsular variations in the silicon level and whether a single measurement would be a valid comparison for the entire breast capsule. This study was then undertaken to measure the variations in tissue silicon levels from multiple sites within each breast capsule sampled. Four patients that underwent silicone breast and three tissue expander explantations were evaluated. All the women had silicone implants for breast augmentation and the placement of tissue expanders for reconstruction following mastectomy. A variety of reasons for explantation were noted. Each of the patient's breast capsules were divided into four quadrants (upper inner, upper outer, lower inner, and lower outer). All samples were harvested in a no-touch technique and were sent for silicon tissue assays. Silicon values ranged from 44 to 9,000 micrograms per gram of tissue and were consistent with our previously measured values. We conclude that random samples of breast capsules reflect the variations within the specimen samples, but can be used to measure elevated silicon values accurately. It is our belief that multiple samples do not need to be taken for each capsule measurement and that a previous potential limitation to the measurements has been eliminated.
在先前的研究中，我们能够展示来自美国不同地理位置的未增强尸体硅组织基线值以及硅胶增强乳房包膜组织的硅含量。这些先前研究的局限性之一是硅含量在囊内存在变化的可能性，以及单次测量对于整个乳房包膜是否是有效的比较。因此开展了本研究，以测量每个采样的乳房包膜内多个部位的组织硅含量变化。对4例接受硅胶隆胸和3例组织扩张器取出术的患者进行了评估。所有女性均接受了硅胶植入隆胸以及乳房切除术后放置组织扩张器进行重建。记录了多种取出植入物的原因。将每位患者的乳房包膜分为四个象限（上内、上外、下内和下外）。所有样本均采用无接触技术采集，并送去进行硅组织检测。硅含量范围为每克组织44至9000微克，与我们先前测量的值一致。我们得出结论，乳房包膜的随机样本反映了样本内的变化，但可用于准确测量升高的硅含量。我们认为，每次包膜测量无需采集多个样本，并且先前测量的一个潜在局限性已被消除。
