超顺磁性氧化铁增强磁共振成像与钆增强磁共振成像在肝脏局灶性病变鉴别诊断中的应用

Superparamagnetic iron oxide--enhanced versus gadolinium-enhanced MR imaging for differential diagnosis of focal liver lesions.

作者信息

Vogl T J, Hammerstingl R, Schwarz W, Mack M G, Müller P K, Pegios W, Keck H, Eibl-Eibesfeldt A, Hoelzl J, Woessmer B, Bergman C, Felix R

机构信息

Department of Radiology, Humboldt-University Berlin, Germany.

出版信息

Radiology. 1996 Mar;198(3):881-7. doi: 10.1148/radiology.198.3.8628887.

DOI:10.1148/radiology.198.3.8628887

PMID:8628887

Abstract

PURPOSE

To assess AMI-25- versus gadolinium-enhanced magnetic resonance (MR) imaging in the differential diagnosis of liver tumors.

MATERIALS AND METHODS

Twenty-nine patients with liver tumors underwent unenhanced, AMI-25-enhanced (15 micromol/kg), and gadolinium-enhanced(0.1 mmol/kg) imaging within 2 weeks.

RESULTS

A significant (P< .05) difference in percentage signal intensity loss (PSIL) was seen in benign tumors on AMI-25-enhanced proton-density-weighted images (nine focal nodular hyperplasia [FNH], 41%; one adenoma, 32.4%) versus malignant tumors. Gadolinium-enhanced T1-weighted gradient-echo images showed strong enhancement in benign lesions (seven FNH, 147.5%; one adenoma, 91.3%) and moderate enhancement in malignant tumors (eight hepatocellular carcinomas, 116.2%, 11 metastases, 39.7%). Receiver operating characteristic analysis revealed a threshold PSIL of 10% on AMI-25-enhanced images as the most essential criteria to distinguish benign from malignant lesions (sensitivity, 88%; specificity. 89%). Interobserver analysis for two observers revealed specificity of 93% for AMI-25-enhanced imaging versus 81.5% for gadolinium-enhanced MR imaging.

CONCLUSION

AMI-25 decreased the SI of benign tumors and helped differentiate benign from malignant tumors.

摘要

目的

评估AMI - 25增强磁共振成像（MRI）与钆增强MRI在肝肿瘤鉴别诊断中的应用。

材料与方法

29例肝肿瘤患者在2周内接受了平扫、AMI - 25增强（15微摩尔/千克）及钆增强（0.1毫摩尔/千克）成像检查。

结果

在AMI - 25增强质子密度加权图像上，良性肿瘤（9例局灶性结节性增生[FNH]，信号强度损失百分比[PSIL]为41%；1例腺瘤，PSIL为32.4%）与恶性肿瘤之间的PSIL存在显著差异（P <.05）。钆增强T1加权梯度回波图像显示良性病变强化明显（7例FNH，强化率为147.5%；1例腺瘤，强化率为91.3%），恶性肿瘤强化程度中等（8例肝细胞癌，强化率为116.2%，11例转移瘤，强化率为39.7%）。受试者操作特征分析显示，以AMI - 25增强图像上10%的PSIL阈值作为区分良性与恶性病变的最重要标准（敏感性为88%；特异性为89%）。两位观察者的观察者间分析显示，AMI - 25增强成像的特异性为93%，而钆增强MRI成像的特异性为81.5%。