Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, 1-2-3 Minami-ku, Hiroshima 734-8553, Japan.
Institute of Engineering Innovation, The University of Tokyo, 7-3-1 Hongo, Bunkyo ku, Tokyo 113-8656, Japan.
Genes (Basel). 2023 Jan 19;14(2):259. doi: 10.3390/genes14020259.
The focus of this brief review is to describe the application of nanoparticles, including endogenous nanoparticles (e.g., extracellular vesicles, EVs, and virus capsids) and exogenous nanoparticles (e.g., organic and inorganic materials) in cancer therapy and diagnostics. In this review, we mainly focused on EVs, where a recent study demonstrated that EVs secreted from cancer cells are associated with malignant alterations in cancer. EVs are expected to be used for cancer diagnostics by analyzing their informative cargo. Exogenous nanoparticles are also used in cancer diagnostics as imaging probes because they can be easily functionalized. Nanoparticles are promising targets for drug delivery system (DDS) development and have recently been actively studied. In this review, we introduce nanoparticles as a powerful tool in the field of cancer therapy and diagnostics and discuss issues and future prospects.
这篇简要综述的重点是描述纳米粒子的应用，包括内源性纳米粒子（如细胞外囊泡、EV 和病毒衣壳）和外源性纳米粒子（如有机和无机材料）在癌症治疗和诊断中的应用。在本综述中，我们主要关注 EV，最近的一项研究表明，癌细胞分泌的 EV 与癌症的恶性改变有关。通过分析其信息性 cargo，EV 有望用于癌症诊断。外源性纳米粒子也可用作成像探针用于癌症诊断，因为它们可以很容易地进行功能化。纳米粒子是药物递送系统（DDS）开发的有前途的靶点，最近受到了广泛的研究。在本综述中，我们将纳米粒子作为癌症治疗和诊断领域的有力工具进行介绍，并讨论相关问题和未来展望。
