Tunç M, Ekinci C
Ankara University Medical Faculty, Turkey.
Acta Cytol. 1996 Mar-Apr;40(2):283-8. doi: 10.1159/000333752.
To define and discuss the cytologic findings in 6 conventional chondrosarcomas (CS), 1 chondroblastic osteosarcoma, 1 extraskeletal myxoid CS and 20 chondroma cases.
Study of fine needle aspiration cytology (FNAC) of cases air dried and May-Grünwald-Giemsa stained.
Tumor cells were embedded in a pink, amorphous, chondroid matrix in conventional CS. They were larger than chondroma cells and had vacuoles and small, pink, chondroid substance-like granules. Chondroblastic osteosarcoma was diagnosed as high grade CS by FNAC, but extremely pleomorphic chondrocytes, osteoid matrix, osteoblastic cells, and clinical and radiologic findings should have produced the proper diagnosis. Extraskeletal myxoid CS had a pinkish, granular, myxoid background. The tumor cells had granulated, dark blue cytoplasm and oval-round, lobulated, slightly indented, hyperchromatic nuclei.
FNAC is efficient for the diagnosis of CS and its variants as long as it is evaluated with radiologic and clinical findings by a pathologist familiar with bone pathology and cytology.
明确并讨论6例传统型软骨肉瘤（CS）、1例软骨母细胞型骨肉瘤、1例骨外黏液性CS及20例软骨瘤病例的细胞学表现。
对空气干燥、经May-Grünwald-Giemsa染色的病例进行细针穿刺细胞学检查（FNAC）研究。
在传统型CS中，肿瘤细胞包埋于粉红色、无定形的软骨样基质中。它们比软骨瘤细胞大，有液泡以及小的、粉红色、软骨样物质样颗粒。软骨母细胞型骨肉瘤通过FNAC诊断为高级别CS，但需结合极其多形性的软骨细胞、类骨质基质、成骨细胞以及临床和影像学表现才能做出正确诊断。骨外黏液性CS有粉红色、颗粒状、黏液样背景。肿瘤细胞有颗粒状、深蓝色的细胞质以及椭圆形至圆形、分叶状、轻度凹陷、核染色质增多的细胞核。
只要由熟悉骨病理学和细胞学的病理学家结合影像学和临床发现进行评估，FNAC对CS及其变异型的诊断是有效的。
