Zdziarska B, Nowacki P
Department of Haematology, Cezary Fryze Medical School, Szczecin.
Acta Haematol Pol. 1996;27(1):43-8.
Clinical and neuropathological investigations were carried out in 6 patients, deceased due to blastic phase of chronic myelogenous leukemia (BPCML). Growth fraction of leukemic cells in peripheral blood, cerebrospinal fluid and in the central nervous system (CNS) was studied, using mitotic index and immunohistochemical staining technique with the monoclonal antibody antiproliferating cell nuclear antigen (anti-PCNA). The results suggest that in BPCML the proliferative activity of leukemic cells is low both in peripheral blood, cerebrospinal fluid, cerebral leukostasis and within the leptomeningeal and intracerebral infiltrates, even in cases with a very high white blood cells count. It can confirm the opinion that in BPCML, accumulation rather than proliferation of leukemic cells plays an important role in the development of the CNS leukemia.
对6例因慢性髓性白血病急变期（BPCML）死亡的患者进行了临床和神经病理学研究。采用有丝分裂指数和抗增殖细胞核抗原单克隆抗体（抗PCNA）免疫组化染色技术，研究外周血、脑脊液和中枢神经系统（CNS）中白血病细胞的生长分数。结果表明，在BPCML中，即使白细胞计数非常高，外周血、脑脊液、脑白细胞淤滞以及软脑膜和脑内浸润灶中白血病细胞的增殖活性也很低。这证实了在BPCML中，白血病细胞的积聚而非增殖在中枢神经系统白血病的发生中起重要作用这一观点。
