Pugina S A, Vorob'ev V G
Ter Arkh. 1993;65(7):33-7.
The investigation of cell composition and different biochemical parameters (ceruloplasmin, lactate dehydrogenase, aldolase, ferritin, beta-2-microglobulin) in cerebrospinal fluid has been performed in 37 patients with chronic myeloid leukemia at different clinicohematological stages. The age of the patients ranged from 16 to 67 years. CNS involvement has been diagnosed in 8 (21.6%) patients by clinical and cytological criteria and in 5 (13.5%) patients on the basis of changes in liquor cytograms and in biochemistry. Morphological substrate of leukemic infiltration may be represented by blast cells and cells of granulocytic line of all stages of differentiation. Direct correlation has been established between ferritin and beta-2-microglobulin levels in liquor and its cytological patterns. This permits a conclusion on possible usage of liquor concentration of beta-2-microglobulin and ferritin measurements as additional tests in the diagnosis of neuroleukemia in chronic myeloid leukemia.
对37例处于不同临床血液学阶段的慢性髓性白血病患者的脑脊液细胞组成及不同生化参数（铜蓝蛋白、乳酸脱氢酶、醛缩酶、铁蛋白、β2微球蛋白）进行了研究。患者年龄在16至67岁之间。根据临床和细胞学标准，8例（21.6%）患者被诊断为中枢神经系统受累，5例（13.5%）患者根据脑脊液细胞图谱和生化变化被诊断为中枢神经系统受累。白血病浸润的形态学底物可能由原始细胞和各分化阶段的粒细胞系细胞代表。脑脊液中铁蛋白和β2微球蛋白水平与其细胞学模式之间建立了直接相关性。这使得可以得出结论，脑脊液中β2微球蛋白浓度和铁蛋白测量值有可能作为慢性髓性白血病神经白血病诊断的附加检查。
