Samaratunga H, Searle J, O'Loughlin B
Department of Anatomical Pathology, Royal Brisbane Hospital, Brisbane, Queensland, Australia.
Aust N Z J Surg. 1996 Jan;66(1):22-5. doi: 10.1111/j.1445-2197.1996.tb00694.x.
Nodular fasciitis is characterized by a proliferation of spindle cells which may be misdiagnosed as sarcomas due to the rich cellularity, mitotic activity and variant morphologic patterns.
This report includes 42 cases of nodular fasciitis and related conditions of skin and soft tissue from the pathology files of the Royal Brisbane Hospital, Queensland, Australia. There were 33 cases of nodular fasciitis, three cases of ossifying fasciitis, three cases of proliferative fasciitis, two cases of proliferative myositis and one case of intravascular fasciitis. Two-thirds of cases were referred from outside Royal Brisbane Hospital.
Nodular fasciitis and ossifying occurred most commonly in young adults with 16 patients (44%) between the ages of 20 and 29. However, the other variants of nodular fasciitis including proliferative myositis and intravascular fasciitis occurred in older people (six patients being older than 49 years) and more commonly occurring in men (n=5). A painless rapidly growing mass was most common. The lesions of nodular fasciitis were most often located in the upper extremity with the forearm most commonly affected.
Nodular fasciitis and related conditions are benign. All patients are alive and well 3 months to 13 years (mean 7.2 years) after simple local resection.
结节性筋膜炎的特征是梭形细胞增生，由于细胞丰富、有丝分裂活性和形态学模式多样，可能被误诊为肉瘤。
本报告包括来自澳大利亚昆士兰州皇家布里斯班医院病理档案中的42例结节性筋膜炎及相关皮肤和软组织疾病。其中结节性筋膜炎33例，骨化性筋膜炎3例，增生性筋膜炎3例，增生性肌炎2例，血管内筋膜炎1例。三分之二的病例是从皇家布里斯班医院以外转诊而来的。
结节性筋膜炎和骨化性筋膜炎最常见于年轻人，16例患者（44%）年龄在20至29岁之间。然而，结节性筋膜炎的其他变体，包括增生性肌炎和血管内筋膜炎，多见于老年人（6例年龄大于49岁），且男性更常见（n = 5）。最常见的表现是无痛性快速生长的肿块。结节性筋膜炎的病变最常位于上肢，前臂最常受累。
结节性筋膜炎及相关疾病为良性。所有患者在单纯局部切除后3个月至13年（平均7.2年）均存活良好。
