Synthesis, physicochemical parameters, and in vitro evaluation of N1-p-chlorophenyl-N5-alkylbiguanides.

A series of N1-p-chlorophenyl-N5-alkylbiguanides were synthesized as potential inhibitors of dental plaque. Partition coefficients and pKa values were determined by standard methods. Biological activity was evaluated against Streptococcus mutans, a pure strain of plaque-forming bacteria. All compounds were compared to chlorhexidine acetate.