Nagata Y, Todokoro K
Tsukuba Life Science Center, Institute of Physical and Chemical Research (RIKEN), Ibaraki, Japan.
Biochem Biophys Res Commun. 1996 Apr 25;221(3):785-9. doi: 10.1006/bbrc.1996.0674.
It has been described that interleukin 3 (IL3) activates JAK2, which in turn stimulates STAT5 activation. We found, however, that IL3 induces tyrosine-phosphorylation of Tyk2 as well as JAK2 in IL3-dependent mouse cell lines, FDC-P2 and Ba/F3. Furthermore, we found that IL3 induces activation of not only STAT5 but also STAT1 and STAT3. Taken together with other observations, these results indicate that IL3, erythropoietin and thrombopoietin share a common JAK-STAT signaling pathway.
据描述，白细胞介素3（IL3）可激活JAK2，进而刺激STAT5的激活。然而，我们发现，在依赖IL3的小鼠细胞系FDC-P2和Ba/F3中，IL3可诱导Tyk2以及JAK2的酪氨酸磷酸化。此外，我们发现IL3不仅可诱导STAT5的激活，还可诱导STAT1和STAT3的激活。结合其他观察结果，这些结果表明IL3、促红细胞生成素和血小板生成素共享一条共同的JAK-STAT信号通路。
