Hoffman R, Paper D H, Donaldson J, Vogl H
Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, UK.
Br J Cancer. 1996 May;73(10):1183-6. doi: 10.1038/bjc.1996.228.
LAM S5 is a polysulphated derivative of the glucan laminarian that inhibits basic fibroblast growth factor (bFGF) binding and the bFGF-stimulated proliferation of fetal bovine heart endothelial (FBHE) cells. This report demonstrates that LAM S5 has anti-angiogenic activity, as shown by inhibition of tubule formation by endothelial cells cultured on Matrigel and inhibition of vascularisation of the chick chorioallantoic membrane. In addition, LAM S5 caused a tumour growth delay of the murine RIF-1 tumour of 2.6 days (P = 0.01).
LAM S5是葡聚糖海带多糖的多硫酸化衍生物，它能抑制碱性成纤维细胞生长因子（bFGF）的结合以及bFGF刺激的胎牛心脏内皮（FBHE）细胞增殖。本报告表明，LAM S5具有抗血管生成活性，这表现为在基质胶上培养的内皮细胞形成小管受到抑制，以及鸡胚绒毛尿囊膜血管化受到抑制。此外，LAM S5使小鼠RIF-1肿瘤的生长延迟了2.6天（P = 0.01）。
